Is Microdosing Good for the Body?

Is taking anything in excess for a long period of time good for the body? It's probably not, right? I think it is healthy to take breaks with things. Do people end up using microdocing as a crutch and then it turns into a multiple time weak thing for many years? And does that have long term impact? "Itis acon er, generally speaking, i think it's safe enough"