Exploring Geroprotective Drugs: Rapamycin, Metformin, NAD, and Resveratrol

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This chapter delves into the potential impact of geroprotective drugs like rapamycin, metformin, NAD, and resveratrol on aging, discussing their origins, studies on their efficacy, and current perceptions. It highlights the need for more research to conclusively prove their benefits in humans and explores the complexities of prescribing these drugs responsibly for longevity. The episode also covers the decline of NAD with age, NAD precursors like NR and NMN in disease treatment, and skepticism around the effectiveness of resveratrol despite its historical significance.

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In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years.

We discuss:

Defining the categories of “proven, promising, fuzzy, noise, and nonsense” [3:15];
Rapamycin [9:30];
Metformin [17:00];
NAD and its precursors [24:30];
Resveratrol [32:45];
The importance of VO2 max, muscle mass, and muscular strength for lifespan [38:15];
Blood flow restriction (BFR) training [44:00];
Using stem cells to treat osteoarthritis or injury [51:30];
Fasting as a tool for longevity (and why Peter stopped his fasting protocol) [55:45];
The energy balance theory [1:06:30];
The idea that sugar is poison [1:12:00];
The idea that sugar substitutes are dangerous [1:22:15];
The debate on red meat and cancer [1:28:45]; and
More.