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The Effects of Nicotine Use on Cognitive Function
There's likely some protective effect of agonizing that nicotinic receptor on long-term cognitive functioning. Too high of a level of nicotinic signaling is certainly not going to be neuroprotective. Same thing for iron levels for example. You don't want low iron levels that are suboptimal and causing things like depression, anxiety, poor sleep and loss of dopaminergic neurons. It's another variable that you want to keep tabs on fairly regularly to make sure that it's not going unnoticed.