Innovative Insights into Organoid Development

This chapter explores the crucial roles of innate immune cells, particularly macrophages, in the morphogenesis of organoids, with a focus on hair and pancreas systems. It highlights the implications of recent studies, including single nucleus RNA sequencing, in understanding the complex interplay between immune and non-immune cells during organ development. Emphasizing the need for novel research methodologies, the chapter discusses the potential of artificial intelligence and drug discovery in advancing therapeutic targets for conditions like cardiac fibrosis.