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Specialized Early Intervention Services vs Treatment as Usual For First-Episode Schizophrenia Spectrum Disorder

JAMA Psychiatry Author Interviews

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Outcomes of the Opus Trial

The chapter discusses the outcomes of the Opus trial, a specialized early intervention program for individuals with first-episode schizophrenia spectrum disorder. It explores the lack of long-term clinical effects after a ten year follow-up, as well as the temporary effect on mortality but no significant effects on psychiatric in-patient or supportive housing facilities after a twenty year follow-up. The limitations of the study and a comparison to other early intervention programs are also discussed.

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