The Effects of Bacteremia on the Hypothalamus

Bacteremia and exogenous pyrogen, endogenous pyrogens get released. This generates like this prostaglandin E2 that increases the hypothalamic set point. Once the set point is increased, once our thermostat is turned up, you feel cold,. You start shivering and you're doing all of these other things to build heat. But by that time, if it's a transient Bacteremia, we will have missed the fever. Right? And for conditions like an endocarditis or an endovascular infection where there's a more persistent Bactseremia, you're more likely to get a positive. So one reason people don't get riger's