Clinical Trials - Are They Going to Rapidly Escalate the Thous?

In a clinical trial, we start with a safety testing phase of like about 20 30 pe. And then we rapidly escalade in numbers because they say, ok, based on this, it looks safe. But at some point there's going to be a young person who seems perfectly healthy, who's got something we don't know about, and is going to die here. So what? What do you want? I mean, the real experiment i'd like to see wasn't done. This was done with a pre variant of concern virus. Want to see omacron. I want to see delta. I wants to see vaccinated versus unvaccinated people,. compare the shedding of infectious virus