Translating Aging cover image

Eliminating Senescent Cells by Activating the Immune System (Robin Mansukhani, Deciduous Therapeutics)

Translating Aging

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Indication Selection for Aging Companies

Brodley: I think indication selection for aging companies is one of the most challenging, under-precated parts of it. We look at it as very broadly in three buckets and now we look at indications. It's about do we believe the model is translatable as it led to successful drugs in the past? Does it have a good burden of senescence that we can measure and quantify differently in our assays? If we actually remove senescence, how does that endpoint translate to the clinic?

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