Epigenetics, Exposome and Intergenerational Effects

Around the world, we’re seeing declining sperm counts, rising infertility, more erectile dysfunction, and lower testosterone—even in younger men. These trends aren’t just affecting family planning; they’re pointing to something much bigger happening in men’s health. Joining me today on The Dr. Hyman Show is Dr. Michael Eisenberg, a Stanford researcher and leading voice in male reproductive health. We talk about why sperm quality matters far beyond fertility—and how everyday health choices quietly shape it. Watch the full conversation on YouTube or listen wherever you get your podcasts. [YOUTUBE THUMBNAIL] We cover: • Why sperm quality may be one of the strongest early indicators of overall health and longevity • How metabolic dysfunction, belly fat, and low testosterone impact fertility and sexual function • The role environmental toxins and endocrine disruptors play in declining sperm counts • What men can do right now to protect fertility and long-term vitality When we look at fertility through the lens of whole-body health, it changes how we think about prevention, risk, and longevity. Male fertility isn’t just about reproduction. It’s a signal. Register for The Ultra Learning Series: Functional Fertility on Thursday, February 12 at 12PM ET here.

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(0:00) Rise in male infertility and testosterone issues

(1:24) Global challenges in men's health and infertility awareness

(4:56) Decline in semen quality and potential causes

(9:52) Reducing exposure to endocrine disruptors and detoxification methods

(14:51) Metabolic health's impact on testosterone and sperm quality as a vital sign

(21:00) Sperm quality biomarkers and the impact of paternal age on offspring

(26:28) Role of paternal health and epigenetics in pregnancy outcomes

(31:29) Lifestyle and supplements to improve sperm quality

(37:57) Stress and environmental factors affecting hormone levels and birth sex ratios

(41:05) Erectile dysfunction: rates, causes, and treatment options

(51:22) Testosterone replacement therapy: benefits and risks

(1:00:08) Andropause and epigenetics in reproductive health

(1:08:22) Rapid fire questions: lifestyle factors affecting sperm quality

(1:09:45) Impact of cycling and sedentary lifestyle on reproductive health

(1:12:46) Importance of sleep, stress management, and relaxation techniques

(1:13:45) Information about swim club and supplements for fertility

(1:14:44) Introduction to the Ultra Learning Series and functional fertility workshop

(1:16:07) Disclaimer and gratitude to sponsors