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May 26 2023 This Week in Cardiology

This Week in Cardiology

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Secubitrolvalsartan and CV Death

Paragon has 4800 patients paraglide enrolled 466 patients the primary endpoint of paraglides cannot be clinical therefore instead they looked at a change in NT pro BNP from baseline through weeks four and eight. The time average reduction in BNP was greater in the secubitrolvalsartan arm and it was a 15% reduction with a p-value of get this 0.049 but there were no substantial differences in CV death. After the trial FDA the sponsors promoted two subgroups that may have benefited more women in dose with EF's at the low end of normal anyways come on I don't even know what to say about this  that's I'm

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