4min chapter

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Dr. Layne Norton: The Science of Eating for Health, Fat Loss & Lean Muscle

Huberman Lab

CHAPTER

Is There a Muscle Protein Synthesis Refractory Period?

This phenomenon is called muscle protein synthetic refractory period. It's also been referred to as the muscle full effect. We saw an increase in AMP kinase, kind of around this mark where protein synthesis started falling off. And we also saw a decrease in intracellular ATP. What we think might be happening is you're consuming protein and you're increasing muscle protein synthesis. But at a certain point, it has enough effect on your energy metabolism in your cells that it kind of, not short circuits it, but it kind of cuts it off.

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