5min chapter

The Immunology Podcast cover image

Ep. 44: “The Innate Immune System” Featuring Dr. Miriam Merad

The Immunology Podcast

CHAPTER

Low Dose IL2 Reduces Inflammatory Gene Expression in Type 1 Diabetes

Low dose IL2 reduces IL21 T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes. It's kind of a paradoxical reaction to high dose IL2. Sometimes low to signaling, high dose signaling have opposite effects on receptors for GPCRs. So they're really trying to understand the mechanism action and existing treatment that they're trying to work on clinically.

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