How to Assess the Risk of Bias in Study Selection?

Risk of bias is crucial, but we have these broader standards. We want to say, what is the quality of the evidence over all that bears on the recommendation? Good. And then you have a problem, the precision. H studies may have little risk of bias, but to small numbers with very wide confidence intervals,. The directness do the results apply to your patience and your context, and them concerns te publication bias. What should be done is part of that, and where should we be looking for possible problems?