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PREPARE II Trial Result Presentation

Critical Care Reviews Podcast

CHAPTER

The Effects of Fluid Bolus on Cardiovascular Collapse

In patients who were not assigned to no fluid bolus, cardiovascular collapse occurred 18.2% of the time. This is a non-statistically significant difference between groups. We also looked at systolic blood pressure occurrence, reading below 65 millimeters of mercury, cardiac arrest, or death and could not identify a subgroup that appeared to be benefited by fluid bolus provision for this indication. And we calculated using a previously validated risk score for a patient's individual risk of experiencing the outcome. Although that risk did indeed seem to predict a patient's probability of experiencing cardiovascular collapse, again, we cannot identify a range of risk at which patients would benefit from fluid bolus.

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