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PREPARE II Trial Result Presentation

Critical Care Reviews Podcast

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The Effects of Fluid Bolus on Cardiovascular Collapse

In patients who were not assigned to no fluid bolus, cardiovascular collapse occurred 18.2% of the time. This is a non-statistically significant difference between groups. We also looked at systolic blood pressure occurrence, reading below 65 millimeters of mercury, cardiac arrest, or death and could not identify a subgroup that appeared to be benefited by fluid bolus provision for this indication. And we calculated using a previously validated risk score for a patient's individual risk of experiencing the outcome. Although that risk did indeed seem to predict a patient's probability of experiencing cardiovascular collapse, again, we cannot identify a range of risk at which patients would benefit from fluid bolus.

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