The Role of Diodenases in Thyroid Functions

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The thyroid gland makes mostly T4 and a little bit of T3. The difference between them has to do with their biologic activity. Diodenases remove one of the iodine's from T4 to create T3, which is the active hormone. When nutrients are scarce, when you need to slow down metabolism, one of the first things that the body does is it increases the production of reverse T3.

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In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options for the treatment of hormone deficiencies. In addition, Peter delves into hormone replacement therapy (HRT), providing nuanced insights into its appropriate usage and the clinical approach he adopts when working with patients.

Peter supplements these explanations with whiteboard illustrations. For a more complete understanding, we highly recommend watching these videos over just listening. The videos can be found on our YouTube channel or on the show notes page.

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