Throughout his career, Penrose has challenged conventional wisdom in physics, mathematics, and the philosophy of science. He has tackled some of the most profound questions of the universe: How do quantum mechanics and cosmology shape our understanding of reality? Can human consciousness be fully explained by physical laws, or does it transcend computation? This wide-ranging conversation spans Penrose’s most influential ideas, from black holes and the Big Bang to Gödel’s incompleteness theorems, quantum gravity, and the role of mathematics in uncovering ultimate reality.