The Oscar Fisher Prize for Novel Ideas That Gaze Beyond Prevailing Theories of Alzheimer's Disease

Nixon and his team may have discovered why the lysosomes in Alzheimer's patients are not acidifying properly. The hypothesized sequence of events in the pathology is murky. Nixon thinks they can be integrated into one entity, which he calls the elephant. If that's true, treatments that target just one protein might not have much of a therapeutic benefit.