The Effects of Genetics on Insulin Resistance

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In skeletal muscle, there are problems with the signaling pathway itself. This includes issues with activities of specific proteins called IRTK, RS1, PI3K, AKET, AKT. Those proteins can be slightly less functioning in certain people based on your genetics. A cluster of these genes that can affect those different proteins involved in insulin signaling can lead to a lower dose of poor lifestyle.

In today’s solo episode and I’ll be talking about insulin resistance, how this impacts your risk of disease and why insulin resistance could drive many chronic conditions and why certain lifestyle measures work for improving metabolic health.

By the end of the episode you will understand:

The relationship between IR and disease

The importance of sugar balance in the body

What insulin is and how insulin works

What happens when we become resistant to insulin

What are the causes of IR

What we can do to become more insulin sensitive and ultimately prevent disease

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References:

4 grams of glucose - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636990/

IR Overview - https://www.ncbi.nlm.nih.gov/books/NBK507839/

Insulin resistance Mechanisms - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831809/

Insulin resistance, genes and mitochondria - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341556/

Obesity Insulin and cancer - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214048/

Insulin resistance from euglycaemic clamps - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379600/

Sleep debt and Insulin resistance - https://pubmed.ncbi.nlm.nih.gov/10543671/

Increased snacking with poor sleep - https://pubmed.ncbi.nlm.nih.gov/19056602/