In our brains, we do a lot less computation every second than the computation done by all those molecules. If there is computational irreducibility, we can't work out in detail what all those molecules are going to do. What we can do is only a much smaller amount of computation. And so the second law of thermodynamics is this kind of interplay between the underlying computational irredUCibility and the fact that we as preparers of initial states or as measures of what happens aren't capable of doing that much computation.