Is There a Difference Between a Can Ask Activation Paradigm and an Epilepsy Model?

In the episode, we sit down with Jeff Binder , M.D. to discuss fMRI from its origins, to its limitations and its future.

Jeff Binder , M.D. is a professor and Vice-Chair for Research in the Department of Neurology at the Medical College of Wisconsin. In 1980, he received his BA in Music. In 1986, received is M.D. from the University of Nebraska Medical Center in Omaha. After further clinical and research training at University of Nebraska Medical Center, Northwestern University, and the Neurological Institute of New York a Presbyterian Hospital, he started at MCW in 1992 where he also began his fMRI research.

Jeff's research focuses on neural systems underlying human language processing and concept representation, speech perception, reading, and aphasia. Much of this work is based on fMRI measurements in healthy people, combined with psycholinguistic and psychophysical measurements of behavior. His clinical practice focuses on patients with aphasia, and he studies the pathological correlates of specific language deficits in these patients using voxel-based lesion-symptom mapping and fMRI. He has also worked extensively on applications of fMRI for presurgical mapping, including development and validation of fMRI language lateralization methods and prediction of language and verbal memory outcomes.

In the episode, we first trace his origin story - from a degree in music to receiving his M.D., then to his early work at MCW and the early days of fMRI. We go on to discuss some of the highlights of his work over his career, including his recent work putting forward the idea of the predominance of experiential-based concept representation in the brain, and that the hubs of this representation are within the default mode network. We also discuss a bit of his early work on characterising and mapping the default mode network, as well as his current work on Aphasic patients. The discussion finishes up with his thoughts on clinical applications of fMRI and how this may be pushed further.

This episode was produced by Jeff Mentch and Stephania Assimopoulos.

Featured artwork "Party Time" by Laura Bundesen.