In this thrilling installment of Impact Theory, Tom Bilyeu sits down with Ben Lamm, visionary founder and CEO of Colossal Biosciences, a company on a mission to reverse extinction and rewrite the future of conservation and synthetic biology. Ben and Tom dive deep into the mind-bending world of de-extinction, synthetic gene editing, and how the CRISPR revolution is not only unlocking the secrets of life—but also actively engineering it.
In Part 1, get ready for a rollercoaster of concepts as Ben explains the technical magic behind gene editing, DNA synthesis, and multiplex genome editing. From the birth of the woolly mouse to the debated revival of dire wolves, Ben reveals the breakthroughs, challenges, and wild stories behind reviving extinct species. You’ll learn how Colossal is using advanced computational biology, AI, and hands-on bioengineering to not only bring animals back but also reshape the future of healthcare, genetics, and ethical decision-making. This is part sci-fi, part practical science, and 100% mind-blowing.
SHOWNOTES
00:00 – Kicking Off: The Mysteries of Editing Life
00:14 – Emergence of the CRISPR Revolution
01:31 – What Is DNA Synthesis and Multiplex Editing?
03:47 – The Woolly Mouse: Engineering Traits Across Species
07:54 – Breaking Down the Process: IVF, Screening, and Sequencing
09:24 – Mapping Genotype to Phenotype and Its Challenges
12:10 – Targeting Gene Edits: From Theory to Application in Health and Conservation
17:09 – From Hair Organoids to Building Mammoth Traits in Mice
24:41 – The Quest for a Universal Egg and Overcoming Cellular Barriers
26:17 – Artificial Wombs: The Next Frontier in Conservation and Science
31:12 – Scaling Conservation and Bridging to Human Healthcare
FOLLOW BEN LAMM
Twitter/X: @federallamm
LinkedIn: Ben Lamm
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