Comparative Analysis of HFNC and NIV in COPD Care

This chapter examines a clinical study that compares high flow nasal cannula (HFNC) therapy to non-invasive ventilation (NIV) for patients with acute exacerbations of COPD experiencing respiratory failure. It discusses the historical context and evolving acceptance of both treatments, while emphasizing evidence from a recent randomized controlled trial and the implications of non-inferiority margins. Additionally, the chapter critiques common medical assumptions and explores the efficacy of HFNC versus NIV in improving patient outcomes.