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Episode 121: The Biology of Pain

The Science of Everything Podcast

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C-Fast Neuronal Sensitivity

C-fibers are unmyelinated and also narrow, both of those mean that they're going to transmit their signals much slower than wider myelinated axons. Being narrow means that essentially there's less room for the traffic to get through if you like. There's more congestion to put it crudely. And so this actually gives rise to something that's called sort of first pain and second pain where typically if you have some sort of tissue damage there'll be an initial very rapid feeling of sorts of intense pain. That is mediated by the a-delta-fiber which is fast being myelinated and wide. You get that single very quickly. Then slightly

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