The hall mark characteristic of ashemer's disease is impaired glucose metabolism, right? So if you do a floridiox glucose pet scan on patients who have alshamers disease, even mild cognitive in paramint, is a decrease in brain energy metabolism. A elevating quitone levels in the blood will increase brain blood flow up to 30%. And i think there are genetic predispositions for people to accumulate these these talks ict like apo efor positive, or somting like that.