Evaluating Prophylactic Cranial Radiation in Extensive Stage Small Cell Lung Cancer

This chapter explores the contentious application of prophylactic cranial radiation (PCI) in extensive stage small cell lung cancer and compares it to its usage in limited stage cases. It discusses the limitations of historical clinical trials, the lack of effective MRI screening, and the recent findings that, while PCI may reduce brain metastases risk, it fails to enhance survival rates and raises concerns about cognitive side effects.