Up to 10% of women aren't able to tolerate synthetic progress drone as an ingredient in birth control because of this impact. Uncontrollable mood swings are often the most common side effects and depression is perhaps one of the most serious. Changes in sleeping patterns and a loss of libido can have a profound impact on how you experience your 20s. Women using birth control with particularly large amounts of estrogen had more instances of depression than those who are on a lower dosage.