The renin angiotensin-eldosterone system puts together a number of organ systems. There is now suggestion that this pathway can happen in tissue as well. So we're going to be talking predominantly about the classical rass system and its involvement in blood pressure, blood volume. But there are non-classical rass systems which tend to be more localised at tissue levels That have effects when it comes to things like... Blood pressure, hypertension. Even diabetes and obesity. Tissues, it can promote fibrosis.