What comes after vibe coding? Maybe vibe researching.

OpenAI’s Chief Scientist, Jakub Pachocki, and Chief Research Officer, Mark Chen, join a16z general partners Anjney Midha and Sarah Wang to go deep on GPT-5—how they fused fast replies with long-horizon reasoning, how they measure progress once benchmarks saturate, and why reinforcement learning keeps surprising skeptics.

They explore agentic systems (and their stability tradeoffs), coding models that change how software gets made, and the bigger bet: an automated researcher that can generate new ideas with real economic impact. Plus: how they prioritize compute, hire “cave-dweller” talent, protect fundamental research inside a product company, and keep pace without chasing every shiny demo.

Timecodes:

0:00 Introduction & Goals of Automated Researcher

0:43 The Evolution of Reasoning in AI

1:46 Evaluations: From Benchmarks to Real-World Impact

5:15 Surprising Capabilities of GPT-5

6:56 The Research Roadmap: Next 1, 2, 5 Years

7:46 Long-Horizon Agency & Model Memory

9:44 Reasoning in Open-Ended Domains

11:18 The Role and Progress of Reinforcement Learning

13:14 Reward Modeling & Best Practices

14:21 The New Codex: Real-World Coding

16:20 AI vs. Human Coding: The New Default

20:07 What Makes a Great Researcher?

21:14 Persistence, Conviction, and Problem Selection

26:00 Building and Sustaining a Winning Research Culture

31:45 Balancing Product and Fundamental Research

39:00 The Importance of Compute and Physical Constraints

45:50 Maintaining Speed and Learning at Scale

47:18 Trust and Collaboration at OpenAI

Resources:

Find Jakub on X: https://x.com/merettm

Find Mark on X: https://x.com/markchen90

Find Sarah on X: https://x.com/sarahdingwang

Find Anjney on X: https://x.com/AnjneyMidha

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Stay Updated:

Find a16z on X

Find a16z on LinkedIn

Listen to the a16z Podcast on Spotify

Listen to the a16z Podcast on Apple Podcasts

Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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September 19, 2025

Letters from an American

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