As we continue our exploration of prostate cancer, we turn our focus to one of the earliest areas where medical oncologists are commonly involved: systemic therapy for non-metastatic prostate cancer. In this episode, we will review how to risk stratify localized prostate cancer, differences in FDA-approved prostate-specific PET tracers, how to evaluate for biochemical recurrence following surgical and radiation based treatments for localized prostate cancer, and when to consider utilizing systemic therapy in non-metastatic disease.

Content:

- A refresher on how we think about systemic treatment options for localized prostate cancer

- What role does imaging play?

- Definition of biochemical recurrence after upfront surgery vs. radiation

- What is castrate-sensitive vs. castrate-resistant disease?

- What to do if someone is already on ADT at the time of recurrence?

- The fundamental design behind the pivotal STAMPEDE trial and the role it plays in helping us care for our patients with localized prostate cancer

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