This chapter explores the crucial role of glutathione as a master antioxidant in protecting DNA, proteins, and fats from damage, emphasizing its significance in detoxification and combatting cognitive decline and neurodegenerative diseases like Parkinson's. Methods to maintain optimal glutathione levels through supplements and dietary sources like cruciferous vegetables are discussed. The chapter also highlights the importance of minimizing exposure to environmental toxins for mitigating the risk of neurodegenerative diseases.

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