Welcome to the metabolism masterclass!

Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast.

From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity.

What You’ll Learn:

• The #1 driver of insulin resistance—and why most doctors miss it

• Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction

• How fasting, cold therapy, and red light impact your metabolism

• The truth about carbs, seed oils, and why some people can’t gain fat

• How to tell if insulin resistance is wrecking your energy & health

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Benjamin’s new book How Not To Get Sick : https://a.co/d/aADlMWv

• Benjamin’s YouTube Page – https://www.youtube.com/@benbikman

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

SPONSORS:

-Lumiram | Go to http://healthlighting.com/dave to save 10% on your order.

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

Timestamps:

00:00 Trailer

00:52 Introduction to Dr. Benjamin Bikman

02:20 The Battle Against Conventional Dietetics

04:12 Understanding Insulin Resistance

06:29 The Two Paths to Insulin Resistance

10:19 Fasting and Metabolic Health

14:11 Insulin and Cognitive Enhancement

18:16 Identifying Insulin Resistance

30:12 The Role of Insulin in Fat Storage

42:04 Understanding Glucose and Insulin Dynamics

42:26 The Role of Exercise in Glucose Regulation

42:54 AMPK and Muscle Contraction

45:21 Calories In, Calories Out Debate

46:15 The Myth of Calorie Counting

50:13 Ketosis and Metabolic Rate

51:14 Intermittent Fasting and Muscle Preservation

55:21 Insulin Resistance and Ketogenic Diets

01:02:04 Circadian Rhythm and Insulin Sensitivity

01:08:08 Environmental Toxins and Insulin Resistance

01:13:03 The Impact of Seed Oils on Insulin Resistance

01:19:22 Final Thoughts and Resources

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