Advancements in Neural Lineage and iPSC Technology

This chapter explores the cutting-edge research in neural lineage identity, focusing on the role of transcription factors and chromatin biology in programming neuronal subtypes. It recounts milestones in the development of induced pluripotent stem cells (iPSCs) and direct reprogramming techniques, while reflecting on the historical significance and evolving potential of these innovations for addressing neurodegenerative diseases. The discussion highlights breakthroughs in cell-based therapies, challenges faced, and the future implications of these advancements on regenerative medicine.