Estrogen Cream for the Face: What the Science Says About Anti-Aging, Collagen, and Hormones
The Dr. Brighten Show
Estriol versus estradiol: safety and use
Jolene compares E3 and E2, noting estriol's minimal systemic absorption and estradiol's greater potency and monitoring needs.
Is estrogen cream for the face really the new holy grail of anti-aging—or is it another skincare trend overselling its promise? In this episode of The Dr. Brighten Show, Dr. Jolene Brighten breaks down the biology behind estrogen and skin aging, why women’s skin often changes rapidly after 35, and what clinical studies actually show about using topical estrogen on the face. This isn’t about chasing youth—it’s about understanding collagen loss, inflammation, and how hormonal shifts during perimenopause and menopause directly affect the skin.
What You’ll Learn in This Episode
In this episode, you’ll learn how estrogen interacts with the skin at a cellular level, why traditional skincare often stops working in midlife, and how clinicians are using estrogen cream for the face—specifically estriol and estradiol—in a thoughtful, medically supervised way. Dr. Brighten explains who may benefit, how these creams are typically used, what results are realistic, and which healthcare providers are qualified to prescribe them, all through a women’s-health-first, evidence-based lens.
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