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[CLASSIC POST] Book Review: The Hungry Brain

Astral Codex Ten Podcast

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The Uncomfortable Dichotomy of Leptin and Weight Gain

While leptin therapy does cause some amount of fat loss, it requires enormous doses to be effective. Some people losing over 30 pounds and others losing little or no weight. This is a far cry from the powerful fat-busting effect of leptin in rodents. Leptin as the numerical weight loss drug never made it to market. The leptin system defends vigorously against weight loss but not so vigorously against weight gain.

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