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The Idea of a Central Paste Maker
The idea that there was a central paste maker started from the work of richter a in, what, the twenties and thirties. And uli schibler showed for the first time that a single cell can generate a 24 hour oscillation. If this brain was destroyed, then those 24 urhythms were lost. We actually understand how those geans and their proteum products interact to generate 24-hour behavior. That information is now being used all the way through to the timing of anti cancer drugs as well as getting an exquisite understanding of night shift or jet lag.