The Limits of Registries

The jack pot study OP 0219 look at the incidence of major adverse cardiovascular events and in there greater than 30,000 patients with more than 54,000 treatment courses showed that they did not have higher rates of mace in patients on jack inhibitors. There are a lot of studies that are actually looking at large data sets claims data registry data long-term open extension data which has tremendous numbers larger than what's in the oral surveillance study. These recreations of data based on files you have in your cabinet don't really cut the muster.