Hosted by Lester Nare and Krishna Choudhary, this one-episode special brings all three 2025 Nobel Prizes in the sciences into a single listen: Medicine (immune tolerance and FOXP3), Physics (macroscopic quantum tunneling in superconducting circuits), and Chemistry (metal–organic frameworks and “new rooms for chemistry”).

Summary

Medicine: Regulatory T cells and the FOXP3 gene that prevent autoimmune disease.
Physics: Macroscopic quantum tunneling and energy quantization in electrical circuits — the bridge to today’s qubits.
Chemistry: Metal–Organic Frameworks (MOFs) — modular porous crystals enabling CO₂ capture, water harvesting, and hydrogen storage.

Show Notes

Nobel Prize Press Release (2025 Medicine)
Nature Genetics (2001) — FOXP3 mutation and IPEX link
Nature Genetics (2001) — FOXP3 Mutation Causes Dysregulation
Nature Genetics (2001) — FOXP3 Gene Cause IPEX Syndrome
Science (2003) — FOXP3 function in regulatory T cells
German Journal of Immunology (1995) — Sakaguchi’s first Treg paper
Nobel Prize Press Release (2025 Physics)
Physical Review Letters (1980s) — Macroscopic Quantum Tunneling Experiments (UC Berkeley)
BCS Theory (1972 Nobel) — Bardeen, Cooper & Schrieffer, University of Illinois
Josephson Effect (1973 Nobel) — Brian D. Josephson
Google Quantum AI Lab — Quantum Supremacy Paper (Nature, 2019)
Nobel Prize Press Release (2025 Chemistry)
Nature (1999) — MOF-5 Discovery (Omar Yaghi et al.)
Science (2003) — Reticular Chemistry Foundations
Journal of the American Chemical Society (1989, 1990) — Richard Robson’s Early Frameworks
Lawrence Berkeley National Laboratory — ChatMOF and AI-Assisted Materials Discovery

FFP EP. 15 | AI-Generated Genomes, Retinal Implants, and Palomar’s Mystery Lights Explained

From First Principles

Training data: PCAWG whole genomes

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