The Intimate Interaction Between Proteins and DNA

DNA has two grooves, a minor groove and a major groove. Different transcription factors interact with different grooves in order to figure out where they're supposed to go. If it's a match, if the protein says, I found my favorite and the environment, and I like what I'm seeing everywhere else as well, what happens in the cell? Like, what does this trigger that would get us excited? Yeah, so you know, this is really funny in that we've spent, as scientists, it was kind of an easier problem to figure out which DNA a particular transcription factor likes to bind.