Pfizer - Gain of Function and Directed Evolution

Pfizer has not conducted gain of function or directed evolution research. The original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS- CoV-2 and near Matt Trellvere at our secure biosafety level 3 laboratory. Most of this work is conducted using computer simulations or mutations of the main protease,. A limited number of cases when a full virus does not contain any known gain of function mutations. Such virus may be engineered to enable the assessment of

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