The Dose Effect Curve

The idea that the dose makes the poison comes from the 1500s with paracelsis basically created that phrase in Italian. We need to understand that things can happen at very low doses and not expect them to be the same thing that we would see at increasing levels. Different mechanisms get activated at different doses. It kind of surprises me where people don't want to recognize the issues or find it difficult to understand that different things happen at different doses, he says.