The Effects of Hormone Replacement Therapy on Estradiol Levels

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A woman has five to ten times more testosterone in her body than she does estradiol. It's not changing all that much, but it is going away when a woman enters menopause. The pituitary gland senses this because there's a negative feedback loop and it says, I want more. When we initiate hormone replacement therapy, we don't want to wait until women are at the peak of their cycle. We want to do it long before that.

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In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system, the adrenal system, and the sex hormone system (for both men and women). He walks through the basic biology and the feedback cycles that regulate the production of these hormones and discusses the various options for the treatment of hormone deficiencies. In addition, Peter delves into hormone replacement therapy (HRT), providing nuanced insights into its appropriate usage and the clinical approach he adopts when working with patients.

Peter supplements these explanations with whiteboard illustrations. For a more complete understanding, we highly recommend watching these videos over just listening. The videos can be found on our YouTube channel or on the show notes page.

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