Is Her-to Mutant Reacting to Immune Checkpoint Inhibitors?

Alk and EGFI have shown no responses to immune checkpoint inhibitors. They-some of them do respond, but it's actually lower than what you expect with the general population. We're in the process of running a randomized phase 3 trial of comparing first-line chemoimmunotherapy versus Trastuzumab, Dirax-Tecan, TDXD in the first-line setting.