Intramuscular vs Subcutaneous Testosterone Explained
The Hunter Williams Podcast
Hematocrit and blood effects
Hunter states IM typically raises hematocrit ~6% versus ~3% with sub-Q, with clinical implications for risk management.
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In today’s episode, I’m breaking down one of the most common—and most misunderstood—questions I get about testosterone therapy: intramuscular (IM) injections versus subcutaneous (SubQ) injections.
Right out of the gate, I want to be clear about something—there is no single “right” answer here. There are different bodies, different lifestyles, different physiologies, and different goals. What I do have is experience, data, and a strong personal preference that I explain openly throughout this episode.
I walk through the actual pharmacokinetics and pharmacodynamics behind IM versus SubQ testosterone—how absorption differs, how peak-to-trough curves behave, how injection frequency changes everything, and why the conversation shifts entirely once you move into every-other-day or daily microdosing instead of once-weekly injections.
We also get into topics most people gloss over or oversimplify: estradiol conversion, hematocrit changes, mood and cognitive stability, libido and sexual function, injection site reactions, mast cell activation, carrier oils, body fat considerations, and why some people feel incredible on one method and awful on the other.
Importantly, this episode is not just for men. I spend time addressing testosterone therapy for women, dosing considerations, concentration issues, and why delivery method matters just as much—if not more—when female physiology is involved.
At the end of the day, my goal isn’t to convince you to inject the way I do. My goal is to give you enough context, data, and real-world nuance so you can make an informed decision, experiment intelligently, and work with your labs instead of against them.
As always, I’m incredibly grateful to be able to do this work and to have a community that actually wants to understand hormones at a deeper level. If you want to stay connected, the email list is where I share things I often can’t say—or haven’t filmed yet.
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