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Using a Base Editor to Change a Mutated Jane That Causes Pegeria
Base editors make single letter swaps in d and a, but they maybe aren't as familiar with what are all the ways you can use those single letter swaps. Prospectively, a base editor could act on any d and a base pair in the genu and making a deterministic change that you can predict. Unlike the consequences of making a double stranded which we can't control, you can control. Verve has used base editors to disrupt a splice sequence in a very precise way. Beam pherapeutics has used this approach in cart cells to knock out genes known to enhance certain kinds of ta herapies.