Overcoming Resistance to Targeted Therapies
The Bio Report
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Targeting P27 for Cancer Therapy
This chapter discusses the role of P27 protein in cancer biology, its relationship with CDK246 kinases, and the potential of drugging P27 as a therapy. The chapter explores the challenges in specifically targeting CDK246 and proposes an alternative approach by blocking CDK246 through P27 inhibition. The speaker also discusses the preclinical work done on their lead therapy, IPY 20, in breast cancer models and the decision to start a biotech company dedicated to developing P27-based drugs.
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