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Ep. 95: “Lymphocyte Signaling” Featuring Dr. Gail Bishop

The Immunology Podcast

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Unraveling Pyroptosis and TCR Engineering

This chapter explores the unique features of pyroptosis, particularly the role of F-actin phillipodia in enhancing immune responses via dendritic cell engagement. It also discusses innovative strategies in T-cell receptor engineering, focusing on the difficulties of specifically targeting cancer antigens while minimizing cross-reactivity. The chapter introduces a novel platform, t-switch, designed to improve T-cell therapies by identifying high-affinity TCR sequences and enhancing their specificity.

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