The Importance of Screening for Latent TB Infection in Adults

Tuberculin skin test and interferon gamma release assays were moderately sensitive and highly specific. Treatment of latent TB infection with recommended regimens reduced the risk of progression to active TB. Isinizid was associated with higher rates of hepatotoxicity than placebo or rifampin. JAMA Editor-in-Chief Kirsten Bibbins-Domingo speaks with U.S.P.F. member Olubenga Agadege from New York University Grossman School of Medicine about the task force's updated recommendations on latent TB infection.