The Importance of Drinking Water

There are two main drivers of thirst: increased osmolarity and angiotensin 2. But there's also this anticipatory thirst that actually bypasses either of these mechanisms using information about what we're eating and drinking. The exact mechanism of the interplay between dopamine, Angiotensin and thirst remains opaque to me. There may be a role for ACE inhibitors in some forms of thirst, like the thirst associated with really high angiotenin 2 levels in CKD.