3min chapter

The Words Matter Podcast with Oliver Thomson cover image

The Clinical Reasoning Series - How can knowledge of mechanisms inform our clinical decision-making? With Dr Elena Rocca and Dr Saúl Pérez-González

The Words Matter Podcast with Oliver Thomson

CHAPTER

Predicting Efficacy and Safety

Evidence of mechanism has all the advantages that we have listed, but it also has some weaknesses. There are some reasons that the evidence of mechanism is ranked so low in the evidence base medicine, internal validity ranking. So what we think, what we try to do is to make a more granular analysis. Sometimes this weakness might be acceptable mit be something we live with.

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