#172: Dom D'Agostino -- The Power of the Ketogenic Diet
The Tim Ferriss Show
Is There a Dangerous Dose of Beta Hydroxybutyrate?
The dose that you need to get a measurable boost in blood ketones is not giving you a dangerous dose of sodium. And I think as the technology sort of evolves and we're creating various types of beta hydroxybutyrate salts from monovalent and divalent cations, what can bind nicely with beta hydroxy butyrate. That's another avenue. We know that we can get levels into the 1 to 2 millimolar range if you take enough.
Dr. Dominic "Dom" D'Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast. Many of you sent enthusiastic follow-up questions after the last conversation we had, so Dom took the time to answer your most popular questions. In particular, he focused on ketosis, ketones, and the ketogenic diet -- so you can consider it the ketosis master class (especially if you combine both episodes, though this one does stand alone). It takes a few minutes for Dom to warm up -- so be patient! If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode. Enjoy! Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you Gymnastic Bodies. This is the training system that I am most obsessed with at the moment. Coach Sommer appeared on a previous episode of the podcast, which turned into a sleeper hit. He is the former USA national team coach for men's gymnastics and creator of this bodyweight-based training system. I'm not easily impressed, and I have been completely blown away by the sophistication and the elegance of his programming. I have been using Gymnastic Bodies for just a few months now, and I already feel more flexible and stronger than I have in years. Check out GymnasticBodies.com/tim, where you'll find the Fundamentals course for diagnosing your weakest areas, those you can tweak for fast improvements. It is incredible. Take a look at GymnasticBodies.com/tim for more details and a large discount. This podcast is also brought to you by Four Sigmatic. I reached out to these Finnish entrepreneurs after a very talented acrobat introduced me to one of their products, which blew my mind (in the best way possible). It is mushroom coffee featuring chaga, which was introduced to me by Laird Hamilton, the king of big wave surfing. You just add the entire packet to hot water. It tastes like coffee, but there are only 40 milligrams of caffeine, so it's got less than half of what you would find in a regular cup of coffee. I do not get any jitters, acid reflux, or any type of stomach burn. It put me on fire for an entire day, and I only had half of the packet! People are always asking me what I use for cognitive enhancement -- right now, this is the answer. You can try it right now by going to foursigmatic.com/tim and using the code "Tim" to get 20 percent off your first order. If you are in the experimental mindset, I do not think you'll be disappointed.
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